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. 2016 Jul 11;6:29361. doi: 10.1038/srep29361

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The model presented here does not show the known effects of HU on RNR. HU targets Fe-S centers in vivo by producing ROS, which delay DNA replication (1–2). Activation of Yap1 decreases ROS levels and increases Fe-S biosynthesis, which in turn attenuates HU-induced Fe-S alteration and improves DNA replication (3).