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. 2016 Jul 11;6:29419. doi: 10.1038/srep29419

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Copyright © 2016, Macmillan Publishers Limited

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(a) PD-L1^−/− mice (n = 4) were immunized with pCI/ppinsΔA_12-21 (d0) followed by an injection of pCI/ppins after 12 days. Furthermore, vaccinated/ppins-primed mice were treated three times (at day 3 before and days 3 and 6 after the injection of pCI/ppins; dashed arrows) with 120 μg anti-CD25 mAb PC61 (left panel) or 120 μg rat IgG1 κ isotype control (right panel). (b) PD-L1^−/− mice (n = 4) were vaccinated with pCI/ppinsΔA12-21 and treated at the same days with anti CD25 mAb as described above, but without the injection of the pCI/ppins vector. Arrows indicate the injection of the diabetogenic pCI/ppins DNA at day 12 post vaccination. Blood glucose levels were measured and cumulative diabetes incidences (%) were determined by regular blood glucose measurements.