Fig.4.

Learning (A) and memory (B) abilities of OBX-mice immunized against different fragments of p75NTR. A) Decreased latency in reaching the saving platform on the 4th day (gray bars) versus that on the 1st day (white bars) of learning is shown. Stars denote significant latency differences between the days: One and two markers are p < 0.05 and 0.01, respectively (Mann-Whitney U-test). B) In session with memory testing, relative (versus “SO+V” control) time spending in the sector where the saving platform was placed during learning was decreased in OBX-mice, with exception of partial recovery for those immunized against p75NTR fragments of 32–46, 155–164, and 167–176. Stars and pluses denote significant differences (one and two markers are p < 0.05 and 0.01, respectively, Mann-Whitney U-test) versus SO and OBX, respectively. A, B) V, KLH, and VP1 denote Vehicle, Keyhole Limpet Hemocyanin conjugate, and a protein from foot-and-mouth disease virus, respectively; error bars show 1 SEM.