Table 3.
Univariate and Multivariate Hazard Rate Ratio Analysis of Patient Characteristics and Sputum Culture Conversion Among Adult Patients With Newly Diagnosed MDR TB in Tbilisi, Georgia, 2011–2014
| Characteristic | Converted 44/52 (84.6%) |
Median (IQR)a | cHR (95% CI) | aHRb (95% CI) |
|---|---|---|---|---|
| N % | ||||
| Age | ||||
| 35–54 | 30/35 (85.7) | 60 (31–92) | 1 | 1 |
| ≥55 | 14/17 (82.4) | 82 (32–94) | 0.90 (.47–1.72) | 0.45 (.19–1.06) |
| Sex | ||||
| Female | 12/15 (80.0) | 61 (32–63) | 1 | 1 |
| Male | 32/37 (86.5) | 74 (32–95) | 0.50 (.24–1.02) | 1.45 (.49–4.28) |
| Household Income | ||||
| ≤$59 | 22/25 (88.0) | 63 (32–94) | 0.97 (.45–2.09) | 0.66 (.25–1.72) |
| $60–$176 | 12/14 (85.7) | 61 (30–77) | 1.66 (.71–3.87) | 0.93 (.32–2.69) |
| ≥$177 | 10/13 (76.9) | 74 (31–95) | 1 | 1 |
| Smoking Status | ||||
| Never smoker | 12/14 (85.7) | 62 (32–89) | 1 | 1 |
| Past smoker | 15/15 (100.0) | 60 (29–92) | 0.97 (.45–2.10) | 0.60 (.20–1.79) |
| Current smoker | 17/23 (73.9) | 84 (32–104) | 0.44 (.19–0.98)c | 0.16 (.04–0.61) |
| Alcohol Use | ||||
| Never | 17/19 (89.5) | 63 (32–87) | 1 | |
| Intermediate | 9/10 (90.0) | 34 (29–94) | 1.06 (.46–2.41) | |
| Heavy | 18/23 (78.3) | 72 (32–99) | 0.58 (.29–1.15) | |
| Imprisonment | ||||
| No | 38/45 (84.4) | 63 (32–94) | 1 | |
| Yes | 6/7 (85.7) | 30 (29–84) | 1.89 (.78–4.57) | |
| Contact with MDR TB Patient | ||||
| No | 41/47 (87.2) | 62 (32–94) | 1 | |
| Yes | 2/4 (50.0) | 17 (0–34) | 3.54 (.80–15.62) | |
| Diabetes | ||||
| No diabetes | 34/41 (82.9) | 60 (31–91) | 1 | 1 |
| Diabetes | 10/11 (90.9) | 91 (62–99) | 0.75 (.36–1.53) | 0.34 (.13–0.87) |
| HIV Status | ||||
| Negative | 42/49 (85.7) | 62 (32–94) | 1 | 1 |
| Positive | 2/3 (66.7) | 78 (29–126) | 0.65 (.15–2.73) | 0.51 (.09–3.06) |
| BMI | ||||
| <18.5 | 7/8 (87.5) | 32 (27–80) | 2.82 (1.18–6.75) | |
| 18.5–24.9 | 29/33 (87.9) | 62 (32–94) | 1 | |
| ≥25 | 8/11 (72.7) | 63 (62–89) | 1.19 (.53–2.68) | |
| Cavitary Disease | ||||
| None | 25/31 (80.7) | 62 (32–94) | 1 | 1 |
| Any cavity | 19/21 (90.5) | 63 (31–92) | 1.31 (.71–2.40) | 2.48 (1.04–5.90) |
| AFB Smear (among culture positive) | ||||
| Negative | 5/8 (62.5) | 32 (29–80) | 1 | 1 |
| Positive | 35/39 (89.7) | 62 (31–94) | 0.66 (.25–1.73) | 0.56 (.17–1.88) |
Abbreviations: AFB, acid-fast bacilli; aHR, adjusted hazard rate ratio; BMI, body mass index; cHR, crude hazard rate ratio; CI, confidence interval; HIV, human immunodeficiency virus; IQR, interquartile range; MDR, multidrug resistant; TB, tuberculosis.
a Among patients who converted, median time (measured in days) from the initial MDR treatment until the first 2 consecutive negative culture results (≥30 days apart).
b Hazard rate ratio after controlling for age, sex, socioeconomic, smoking status, diabetes status, HIV status, cavitary disease, and AFB smear. Empty cells mean that the variables were not included in the multivariate model.
c Bold indicates that the finding is statistically significant at level of confidence of 5% (P < .05).