Table 4.

Demographics, Clinical Characteristics, and Mycological Data of Patients With Rare Invasive Fungal Diseases

IFD due to Rare Fungi	Age	Gender	Category of Patient	Sample Providing Diagnosis	Diagnostic Element	Location of Fungal Infection	BG at TOD
							Time Interval Between Sample Providing Diagnosis and BG Sample (Days)	BG Value (pg/mL)
Cryptococcosis	5	F	Non-IC	Blood culture	Cryptococcus neoformans	Blood, Meninges, Lymph nodes	6	<80
	55	F	Hematology	CSF	C. neoformans	Meninges	1	244
	57	M	HIV	CSF	C. neoformans	Blood, Meninges, Urine	4	<80
	56	F	SOT	Serum	Positive cryptococcal EIA antigen	Meninges, Skin, Urine	0	89
	43	M	SOT	Sputum	C. neoformans	Lung	5	<80
	48	F	SOT	CSF	C. neoformans	Meninges	1	<80
	60	M	HIV	Pulmonary biopsy	Encapsulated yeasts at Grocott staining	Lung	−1	342
	18	F	Hematology	Blood culture	C. neoformans	Blood	−1	<80
	62	M	SOT	CSF	C. neoformans	Meninges	0	<80
	17	F	SOT	CSF	C. neoformans	Meninges	8	<80
Zygomycosis	69	F	SOT	Cutaneous biopsy	Mucor irregularis	Skin and subcutaneous tissue	6	144
	4	F	SOT	Gastric biopsy	Lichtheimia sp	Gastrointestinal tract	1	158
	22	M	Hematology	Sinus biopsy	Rhizopus sp	Sinus	0	134
	66	F	Hematology	Sinus biopsy	Lichtheimia ramosa	Sinus	−1	<80
	8	F	SOT	Cutaneous biopsy; Serum	Rhizopus oryzae	Skin and subcutaneous tissue	10	<80
IFD due to Fusarium sp	70	F	Hematology	Blood culture	Fusarium solanii	Blood	2	99
	61	F	SOT	Sputum	Fusarium sp	Lung	0	<80
	42	M	Hematology	Blood culture	Fusarium sp	Blood	10	<80
	62	F	Hematology	Blood culture	Fusarium proliferatum	Blood	0	<80
IFD due to Trichosporon sp	33	M	Hematology	Blood culture	Trichosporon sp	Blood	1	>523
	67	F	Hematology	Blood culture	Trichosporon sp	Blood	9	>523
	10	F	ICU	Blood culture	Trichosporon asahii	Blood	6	<80
IFD due to Rhodotorula sp	3	M	ICU	Blood culture	Rhodotorula mucilaginosa	Blood	4	184
	2	M	Hematology	Blood culture	R. mucilaginosa	Blood	5	<80
IFD due to Geotrichum sp	72	M	Hematology	Blood culture	Geotrichum capitatum	Blood	0	287
IFD due to Malassezia sp	4	M	Hematology	Blood culture	Malassezia furfur	Blood	3	<80
IFD due to Acremonium sp	63	M	Hematology	Blood culture	Acremonium strictum	Blood	0	<80
Infection due to Trichoderma sp	67	F	SOT	BAL	Trichoderma longibrachiatum	Lung	3	489
IFD due to Exophiala sp	8	F	Hematology	CSF	Exophiala dermatitidis	Brain, Meninges	−3	>523
IFD due to Cladophialophora sp	6	M	Non-IC	CSF	Cladophialophora bantiana	Brain	6	145
IFD due to Rasamsonia sp	29	M	Hematology	Cutaneous abscess	Rasamsonia argillacea	Lung, Skin, Subcutaneous tissue	1	<80
Histoplasmosis	43	F	HIV	Bone marrow aspiration	Histoplasma capsulatum	Bone marrow, Lymph nodes, Skin	2	233
	36	F	HIV	Bone marrow aspiration	H. capsulatum	Disseminated	3	255
Coccidioidomycosis	32	M	Non-IC	Sputum	Coccidioides immitis	Lung (relapse)	0a	150
IFD due to Scedosporium sp	69	F	SOT	Bone biopsy	Scedosporium apiospermum	Lung, Bone, Eye, Blood	2	>523
	14	M	Hematology	Sputum	Scedosporium prolificans	Lung, Blood	1	<80
	32	M	Cystic fibrosis	Sputum	Scedosporium sp	Bone (relapse), Disseminated	7b	270
	52	F	SOT	Cutaneous sample	S. apiospermum	Subcutaneous tissue, Bone	0	<80
Invasive cutaneous phaeohyphomycosis	62	M	SOT	Cutaneous biopsy	Alternaria infectoria	Skin, Subcutaneous tissue	0	>523
	58	F	SOT	Cutaneous biopsy	Alternaria rosea	Skin, Subcutaneous tissue	−4	298
	63	M	SOT	Cutaneous biopsy	Phialemonium dimorphosporum	Skin, Subcutaneous tissue	3	>523
Deep dermatophytosis	72	M	SOT	Cutaneous biopsy	Trichophyton rubrum	Skin, Subcutaneous tissue	−2	151
	56	M	SOT	Cutaneous biopsy	T. rubrum	Skin, Subcutaneous tissue	1	>523
Eumycotic mycetoma	34	M	Non-IC	Cutaneous biopsy	Madurella mycetomatis	Lumbar subcutaneous tissue, Lung, Pleura, Retroperitoneum	0c	254
	59	M	SOT	Cutaneous biopsy	Nonidentified black fungus	Subcutaneous tissue	1d	304
	69	M	Diabetes	Cutaneous biopsy	Exophiala jeanselmei	Subcutaneous tissue	0	305
	68	M	SOT	Cutaneous biopsy	F. solanii	Subcutaneous tissue	0	337
	54	M	SOT	Grains in seropurulent exudate	Nonidentified fungus	Subcutaneous tissue	0	237

Abbreviations: BG, (1-3)-β-d-glucan; BAL, bronchoalveolar lavage; CSF, cerebral spinal fluid; EIA, enzyme immunoassay; HIV, human immunodeficiency virus; ICU, intensive care unit; IFD, invasive fungal diseases; Non-IC, non-immunocompromised; SOT, solid organ transplant; TOD, time of diagnosis.

^a The initial diagnosis of pulmonary coccidioidomycosis was performed 21 months before the current relapse.

^b The initial diagnosis of spondylodiscitis due to Scedosporium sp was performed 4 years before the current relapse.

^c The initial diagnosis of the eumycotic mycetoma was performed 13 years before the current onset.

^d The initial diagnosis of the eumycotic mycetoma was performed 24 years before the current onset.