Figure 3.

Surface representation of the MT1-MMP HPX domain with the residues exhibiting the largest decrease in NMR signal intensity in the presence of: (A) 1% w/v bicelles (the residues interacting selectively with bicelles are colored in magenta, while those affected also by the addition of CHAPS are colored in blue); (B) 10 μL of pellet containing 2.0 × 10⁶ HEK293T cells (in magenta); (C) THP (molar ratio HPX:THP = 1:0.5) (in blue): (D) 1% w/v bicelles and THP (molar ratio THP:HPX = 1:1) (in magenta and blue, respectively). The residues affected by the binding to bicelles, whose signal intensity increases with the addition of THP, have been highlighted in yellow in panel D.