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Mistranslation can be beneficial in response to stress. Under stress conditions or in organisms with editing-defective aaRS, aaRS could misacylate noncognate amino acid which can be used in translation to make mutant proteins. Mutant proteins derived from mistranslation can misfold, aggregate, or perform functional roles to respond to stress and help adapt to environmental changes. AA, amino acid; aaRS, aminoacyl-transfer RNA synthetase.
