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. 2016 Jul 1;13:175. doi: 10.1186/s12974-016-0640-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Alterations in MHC-related genes and MHCI protein induced by long-term THP treatment. a Confocal analysis of THP-treated aging brains revealed decreased MHCI-positive cells. Scale bar = 50 μm. b qRT-PCR revealed mRNA encoding MHC genes (H2-Ea, MR1, Cd74, RT1-CE12), and COL1a2 is significantly downregulated by THP in the hippocampus (mean ± SD, n = 3). *P < 0.05, **P < 0.01 compared with the younger group (3 months old); &P < 0.05, &&P < 0.05 compared with the NS-treated aging group (Dunnett’s test)