Fig. 3.

Chronic periodontal infection and concomitant collagen immunization aggravates experimental arthritic pathological change. Histological assessment of ankle joints after immunization with collagen type II (CII). a Synovial joint inflammation, b pannus formation and c skeletal damage scores on H&E-stained tissue sections. Data are mean + SEM (scale 0–3) of six mice per group. d Histopathological evidence of development of arthritis in B1O.RIII mice. H&E staining of ankle joint tissue from B10.RIII mice (top row). H&E staining of paw tissue from B10.RIII mice (bottom row). Yellow arrowheads indicate inflammatory infiltration; thick blue arrows indicate pannus formation and thick black arrows indicates cartilage destruction. Original magnification ×20. N = 6 in each group. Cont control, Pg/Td/Tf, P. gingivalis/T. denticola/T. forsythia