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. 2015 Jan 21;7:3. doi: 10.1186/s13195-014-0080-3

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© Clark et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Hypothesized relationships depicting elevation in CVRi in the very-old resulting from increased MAP and reduced CBF. CBF, cerebral blood flow; CVRi, index of cerebrovascular resistance; MAP, mean arterial pressure.