Table 4.
Summary of nucleotide substitutions found in the full‐length HA sequences by group
| Group | Type of substitutiona | Effectb | Nucleotide | Regionf | Frequencyg | ||
|---|---|---|---|---|---|---|---|
| Ref.c | Posd | Vare | |||||
| NAIVE (n = 16)h | Transition | SM | C | 282 | T | HA1 | 1 |
| Transition | NSM | A | 15 | G | Sig_pep | 1 | |
| Transition | NSM | G | 515 | A | HA1 | 5 | |
| Transversion | NSM | A | 617 | C | HA1 | 1 | |
| PASSIV‐VAC (n = 9) | Transition | SM | T | 1194 | C | HA2 | 1 |
| Transition | NSM | G | 515 | A | HA1 | 6 | |
| Transition | NSM | A | 563 | G | HA1 | 1 | |
| Transversion | NSM | G | 454 | C | HA1 | 1 | |
| Transversion | NSM | A | 1382 | C | HA2 | 1 | |
a
Type of substitution compared with the reference sequence.
b
Base pair substitution effect on the hypothetical translated protein (SM, synonymous mutation, NSM, non‐synonymous mutation).
c
Reference nucleotide according to reference sequence.
d
Position‐based HA numbering.
e
Variant nucleotide.
f
HA region where the substitution was found.
g
Frequency: number of times the specific difference was observed.
h
Number of full‐length HA sequences.