Table 8.
Summary of hypothetical amino acid substitutions found in HA by group
| Group | Region | Amino acid positiona | Amino Acid | Sited | Frequencye | Chemical naturef | |
|---|---|---|---|---|---|---|---|
| Ref.b | Var.c | ||||||
| NAIVE | H1 | NAg | NA | NA | – | 1 | NA |
| Sig_pep | 5 | Isoleucine | Methionine | – | 1 | Hydrophobic to hydrophobic | |
| H1 | 155 | Glycine | Glutamate | B | 5 | Polar to charged | |
| H1 | 189 | Glutamine | Proline | B | 1 | Polar to hydrophobic | |
| PASSIV‐VAC | H2 | NA | NA | NA | – | 1 | NA |
| H1 | 155 | Glycine | Glutamate | B | 6 | Polar to charged | |
| H1 | 171 | Lysine | Arginine | D | 1 | Charged to charged | |
| H1 | 135 | Alanine | Proline | A | 1 | Hydrophobic to hydrophobic | |
| H2 | 204 | Asparagine | Threonine | – | 1 | Polar to polar | |
a
Numbering for each hypothetical protein.
b
Ref: Amino acid predicted in the reference sequence.
c
Var: Amino acid predicted in the variant sequence.
d
Site: Antigenic site where the substitution was mapped.
e
Frequency: number of times the specific difference was observed.
f
Chemical nature of the amino acid substitution.
g
NA: No applicable (synonymous mutation).