BAT activation induced by means of cold exposure but not sympathomimetic treatment. Coronal 18F FDG PET (left column), CT (middle column), and fused PET/CT (right column) images in healthy volunteer after control saline treatment (top row), ephedrine treatment (middle row), or cold treatment by means of a cooling vest (bottom row). Arrowheads indicate tracer uptake specifically in response to cold treatment. (Reprinted, with permission, from reference 41.)