Skip to main content
. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Pediatr Neurol. 2016 Jan 11;58:31–36. doi: 10.1016/j.pediatrneurol.2015.10.015

TABLE 3.

Anticonvulsant Neuroscore and Side Effect Comparisons

Were Median Neuroscores at
This Visit Different for Those
With a History of Use? (P Value)
Were Median Neuroscores
Different for Those Currently
Using This AED at This Visit? (P Value)
Were More or Fewer Side
Effects Reported for Those
on This AED at This Visit? (P Value)
Clobazam Higher:
  •Recent SZ (0.04)
None significant None significant
Lamotrigine Higher:
  •Visit 1 SZ (0.03)
  •Visit 1 SZ (0.01)
Higher:
  •Visit 6 SZ (0.02)
None significant
Levetiracetam Higher:
  •Visit 5 SZ (0.008)
  •Visit 6 SZ (0.001)
  •Visit 7 SZ (0.006)
  •Visit 10 SZ (0.03)
  •Recent SZ (0.01)
Higher:
  •Visit 6 SZ (0.02)
More reported ≥1 SE:
  •Visit 1: (0.006)
Oxcarbazepine None significant None significant Fewer reported ≥1 SE:
  •Recent: (<0.05)
Fewer reported weight SEs:
  •Recent: (<0.04)
Phenobarbital Higher:
  •Visit 10 SZ (0.03)
  •Visit 11 SZ (0.02)
  •Recent SZ (0.03)
None significant None significant
Topiramate Higher:
  •Visit 1 SZ (0.006)
  •Recent SZ (0.04)
None significant None significant
Valproate None significant None significant More reported ≥1 SE:
  •Recent: (0.02)
More reported weight SEs:
  •Visit 1: (0.003)
  •Recent: (0.001)
Zonisamide Higher:
  •Visit 1 SZ (<0.001)
  •Visit 3 SZ (<0.05)
  •Recent SZ (0.003)
Higher:
  •Visit 1 SZ (<0.002)
  •Recent SZ (0.03)
None significant

Abbreviations:

AED = Anticonvulsant

SE = Side effects

SZ = Seizure score