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. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: Cell. 2015 Dec 3;163(6):1444–1456. doi: 10.1016/j.cell.2015.10.072

Figure 2. Hematopoietic/endothelial IL-18, but not IL-18R, promotes DSS-induced colitis.

Figure 2

(A) Weight loss of cohoused Il18fl/fl and Il18Δ/HE littermates treated with 2% DSS for 7 days (n=4). (B) Colonoscopy severity score of Il18fl/fl and Il18Δ/HE mice on day 7 and 11. (C) Weight loss of cohoused Il18rfl/fl and Il18rΔ/HE littermates (n=6). (D) Colonoscopy severity score of Il18rfl/fl and Il18rΔ/HE mice on day 7. (E) Representative H&E staining of distal colon sections obtained from cohoused Il18rfl/fl and Il18rΔ/HE mice given water (top) or DSS (bottom) and assessed on day 8. Scale bar = 25 μm. Data are represented as mean ± SEM. *, p<0.05; **, p<0.01; ***, p<0.001; by unpaired Student’s t-test. Related to Figure S1–3.