Table 4.
Conserved sequence motifs in the PITP-domain.
| Motif Identifier | secondary structure element, PITPαa | Sequence rangeb: PITPα PITPnm1 PITPNC1 |
Motif sequenceb: PITPα PITPnm1 PITPNC1 |
|---|---|---|---|
| 1 | sheet 1 (3-11) | 2-9 | 2-VLLKEYRV-9 |
| 1 | 1-8 | 1-MLIKEYHI-8 | |
| 1 | 1-8 | 1-MLLKEYRI-8 | |
| 2 | helix A (14-33) | 12-24 | PVSVDEYQVGQLY |
| 2 | 11-23 | PMSLDEYQVAQLY | |
| 2 | 11-23 | PLTVDEYKIGQLY | |
| 3 | - | -------- | |
| 3 | 24-31 | MIQKKSRE | |
| 3 | 24-31 | MISKHSHE | |
| 4 | helix A (14-33) | 26-36 | VAEASKNETGG |
| 4 | - | ----------- | |
| 4 | - | ----------- | |
| 5 | sheet 2 (39-49) | 37-48 | GEGVEVLVNEPY |
| 5 | 37-48 | GSGVEILANRPY | |
| 5 | 36-47 | GEGVEVVQNEPF | |
| 6 | sheet 3 (55-64) | 55-64 | GQYTHKIYHL |
| 6 | 56-65 | GQYTHKVYHV | |
| 6 | 55-64 | GQFTEKRVYL | |
| 7 | helix B (70-75) | 66-73 | SKVPTFVR |
| 7 | 204-211 | AKIEQFIH | |
| 7 | 198-205 | TRVEQFVH | |
| 8 | - | ----------- | |
| 8 | 69-79 | IPGWFRALLPK | |
| 8 | 68-78 | LPSWARAVVPK | |
| 9 | 76-86 | APEGALNIHEK | |
| 9 | - | ----------- | |
| 9 | - | ----------- | |
| 10 | sheet 4 (84-91) | 87-96 | AWNAYPYCRT |
| 10 | 88-97 | SWNAYPYTRT | |
| 10 | 86-95 | AWNYYPYTIT | |
| 11 | - | -------- | |
| 11 | - | -------- | |
| 11 | 97-104 | YTCSFLPK | |
| 12 | - | -------- | |
| 12 | 98-105 | RYTCPFVE | |
| 12 | - | -------- | |
| 13 | sheet 5 (94-100) | 99-106 | TNEYMKED |
| 13 | - | -------- | |
| 13 | - | -------- | |
| 14 | sheet 6 (108-117) | 107-120 | FLIKIETWHKPDLG |
| 14 | 107-120 | FSIEIETYYLPDGG | |
| 14 | 105-118 | FSIHIETKYEDNKG | |
| 15 | helix C (132-137) | 123-134 | ENVHKLEPEAWK |
| 15 | - | ------------ | |
| 15 | - | ------------ | |
| 16 | - | ----------------------- | |
| 16 | 124-146 | NVFNLSGAERRQRILDTIDIVRD | |
| 16 | - | ----------------------- | |
| 17 | sheet 7 (138-142) | 137-144 | EAVYIDIA |
| 17 | - | -------- | |
| 17 | 134-141 | EVCFIDIA | |
| 18 | 153-160 | DYKAEEDP | |
| 18 | 152-159 | EYKAEEDP | |
| 18 | 149-156 | YYKESEDP | |
| 19 | 163-173 | FKSIKTGRGPL | |
| 19 | 162-172 | YHSVKTGRGPL | |
| 19 | 159-169 | FKSEKTGRGQL | |
| 20 | helix E (177-183) | 175-183 | PNWKQELVN |
| 20 | - | --------- | |
| 20 | - | --------- | |
| 21 | sheet 8 (191-201) | 190-206 | MCAYKLVTVKFKWWGLQ |
| 21 | 187-203 | MCAYKLCKVEFRYWGMQ | |
| 21 | 181-197 | MCSYKLVTVKFEVWGLQ | |
| 22 | helix F (206-232) | 207-214 | NKVENFIH |
| 22 | - | -------- | |
| 22 | - | -------- | |
| 23 | helix F (206-232) | 217-224 | ERRLFTNF |
| 23 | - | -------- | |
| 23 | - | -------- | |
| 24 | helix F (206-232) | 225-244 | HRQLFCWLDKWVDLTMDDIR |
| 24 | 223-242 | HRQAWCWQDEWTELSMADIR | |
| 24 | 216-235 | HRQAFAWVDEWYDMTMDEVR | |
| 25 | helix G (240-261) | 245-253 | RMEEETKRQL |
| 25 | 243-252 | ALEEETARML | |
| 25 | - | ---------- | |
| 26 | - | -------- | |
| 26 | 294-301 | PPGPDASP | |
| 26 | 269-276 | RSAPSSAP |
a
Secondary structure nomenclature for rat PITP as defined in [22], parenthesis indicate the complete range of the secondary structure element.
b
Sequences and residue numbering refer to human proteins, PITPα is gi:5453908, tracking #38; PITPnm1 is gi:18490106, tracking #21; PITPNC1 is gi:32307140, tracking #7. PITPNC1 is also called rdgBβ.