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. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: N Engl J Med. 2011 Nov 1;365(20):1896–1904. doi: 10.1056/NEJMoa1110212

Table A.11.1a.

Adjusted Hazard Ratios for Serious Cardiovascular Events, According to Use of ADHD Medications, Restricted to New Users of ADHD Medications.

ADHD medication use Person-
years
Events Rate/100,000
person-years
Hazard
Ratio
95%
confidence
interval
Nonuser 1,597,962 49 3.07 1.00 Reference
Former user 376,456 19 5.05 1.13 0.60–2.13
Current User 192,040 4 2.08 0.73 0.24–2.10

Hazard ratios estimated with Cox regression models which included site-specific propensity score decile, site, medical conditions (serious cardiovascular disease, serious chronic illness), psychiatric conditions (major psychiatric illness, substance abuse, and antipsychotic use), utilization variables (medical hospitalization and general medical care access), age, and calendar year.