Fig. 4.

HSCs from Ts65Dn mice are more sensitive to radiation-induced suppression of clonogenic function than HSCs from wild-type mice. Panel A: Percentage of colony-forming HPCs in single-sorted HPCs from Ts65Dn and wild-type mice after sham (control) or 2 Gy irradiation in vitro. Panel B: Percentage of colony-forming HSCs in single-sorted HSCs from Ts65Dn and wild-type mice after sham (control) or 2 Gy irradiation in vitro. The data are presented as mean ± SD (n = 3 mice per group). *P < 0.05 and ***P < 0.001 vs. WT.