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. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 May;49(5):2178–2192. doi: 10.1167/iovs.07-0632

Figure 4.

Figure 4

SDF-1/CXCR4 axis in a 12-WG fetal eye. Low-magnification micrographs showing SDF-1 (A) and CXCR4 (B) from the peripapillary region adjacent to the optic nerve head (arrowhead) to the far periphery (paired arrows). In the far periphery, SDF-1 was more intense in the region where CXCR4+ precursors had not yet migrated (paired arrows). (C, D) Higher magnification of the peripheral retina showing more intense SDF-1 in advance of (paired arrows) CXCR4+ precursors. (E, F) Higher magnification of the peripapillary region showing less intense SDF-1 immunoreactivity than in the far periphery. CXCR4 immunoreactivity was present throughout the NFL at this age but was less intense than in the INL. Arrowhead: ILM. Stain: APase/NBT reaction product after bleaching. Scale bar: (A) applies to (B); (C) applies to (DF).