Fig. 6.—

Diversity of invasin_beta β-barrel domain proteins extends beyond the inverse autotransporter family. A protein–protein similarity network of all sequences annotated with an invasin_beta domain (reduced to identity 0.9). The inset frames the majority of sequences which cluster tightly, the colors correspond to the sequence groups as shown in fig. 3. Sequences were observed with both a pectin lyase domain and the invasin_beta translocation device. This is comparable with canonical autotransporters such as pertactin (inset); these Type Va autotransporters often have an additional protease domain indicated by the green icon (“P”).