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. 2016 Jun 11;8(6):1906–1916. doi: 10.1093/gbe/evw125

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© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 4.— — Novel BGCs for arseno-organic metabolites found in Actinobacteria. The BGCs were found by mining for the co-occurrence of arsenoenol pyruvate synthase (AEPS), arsenopyruvate mutase (APM). Related BGCs were only found in actinomycetes. The phylogeny was constructed with a concatenated matrix of conserved enzymes among the BGCs including AEPS, APM, and CTP synthase. Variations in the functional content of the BGCs are accounted by genes indicated with different colors. Three main classes or arseno-organic BGCs could be expected from this analysis: PKS-NRPS independent (black names), PKS-NPRS-hybrid dependent (red names), and PKS-dependent biosynthetic systems (blue names).