Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 11;8(6):2036–2043. doi: 10.1093/gbe/evw135

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Fig. 2.— — HHZ Regions 3 and 4. (a) Schematic diagram of the Region 3 within the HHZs of several K. pneumoniae strains. The DNA sequences surrounding the hot spot and inserted fragments are represented in blue. The inserted regions are shown in thinner lines with different colors to indicate that the sequences are different. The sequences inserted in strains Kb140, Kb677, and VA360 are identical. The coordinates are those found in GenBank. The hot spot sequences, also known as attO (Lin et al. 2008), are red and the sequences immediately adjacent to the hot spots are black. In the case of strain NTUH-K2044 the inserted sequenced is the ICEKp1 pathogenicity island. (b) Schematic comparison of the Region 4, which consists of the CPC, within the HHZs of K. pneumoniae strains Kb140, Kb677, and VA360. Grayed regions represent high homology. In those cases where there is no 100% identity, the identity percentage is shown. In the case of strain VA360, the Region 4 was put together using different contigs, which are identified by their accession numbers. Coordinate numbers are those in GenBank. Potential function of genes (Kelly and Whitfield 1996; Whitfield 2006; Shu et al. 2009): uge, UDP-galacturonate 4-epimerase; ugd, UDP-glucose dehydrogenase; ATF, acyl transferase; gnd, gluconate-6-phosphate dehydrogenase; wcaJ, undecaprenyl-phosphate glycosyltransferase; GTF, glycosyl transferase; POL, polysaccharide biosynthesis; int, integrase-like; tnp, transposase-like; cpsF, CMP-N-acetylneuraminic acid synthetase; tcd, glycosyltransferase; OAL, O-antigen ligase; etk, tyrosine-protein kinase; wza, polysaccharide export lipoprotein; wzi, integral outer membrane protein; PAP2, PAP2 superfamily; galF, modulator of GalU to elevate the cellular concentration of UDP-glucose; Hyp, hypothetical; epsG, putative capsular polysaccharide biosynthesis protein; rfbX (wzx), flippase; wcaG, GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/reductase; rfbAB, ATP-binding cassette transporter; rfbC, involved in polysaccharide synthesis (epimerase), rfbD, involved in polysaccharide transport; wbaP, membrane protein that helps transfer a galactose residue from UDP-Gal to undecaprenol diphosphate to form Gal-p-UndP.