Table 1.

Baseline thermal and mechanical nociceptive thresholds in wild-type (WT), prolactin null-mutant (PRL KO) and prolactin receptor null-mutant (PRLR KO) female and male mice.

	WT vs PRL KO			WT vs PRLR KO
	Heat	Cold	Mechanical	Heat	Cold	Mechanical
Female	9.12±0.45 vs 8.21±0.24 (ns)	4.11±0.30 vs 8.08±0.65(**)	7.92±0.43 vs 7.41±0.54 (ns)	8.42±0.37 vs 7.54±0.28 (ns)	3.63±0.35 vs 6.88±0.26 (***)	7.71±0.49 vs 7.16±0.61 (ns)
Male	10.08±0.46 vs 9.45±0.52 (ns)	7.28±0.59 vs 8.46±0.57 (ns)	8.35±0.42 vs 8.01±0.37 (ns)	9.22±0.43 vs 8.46±0.38 (ns)	6.68±0.53 vs 7.39±0.72 (ns)	8.02±0.33 vs 7.73±0.66 (ns)

N=8-10. Significant changes (unpaired t-test) are in brackets: ns – non-significant

^**p<0.01

^***p<0.001.

Heat nociception is measured as paw withdrawal latency (PWL) in seconds.

Cold nociception is measured in threshold temperature in degrees (°C).

Mechanical nociception is measured in threshold force in grams (g).