Table 4.

Multivariable Cox Regression Analysis for All‐Cause Death, Using Weight Loss as Continuous Variable

	Total			Nonobese			Obese
	N=1000			N=725			N=275
	HR	95% CI	P Value	HR	95% CI	P Value	HR	95% CI	P Value
Weight lossa	1.34	(1.18–1.61)	0.002	1.29	(1.04–1.60)	0.02	1.67	(1.19–2.33)	0.003
Age	1.03	(1.02–1.05)	<0.001	1.04	(1.02–1.05)	<0.001	1.04	(1.01–1.08)	0.02
Female sex	0.74	(0.51–1.08)	0.12	0.74	(0.47–1.18)	0.21	0.46	(0.22–96)	0.04
Ischemic etiology	1.60	(1.14–2.26)	0.007	1.43	(0.94–2.17)	0.09	2.62	(1.35–5.10)	0.004
HF duration	1.00	(1.00–1.01)	0.001	1.00	(1.00–1.01)	<0.001	1.00	(1.00–1.01)	0.64
LVEF	1.00	(0.98–1.01)	0.43	0.99	(0.98–1.01)	0.26	1.00	(0.98–1.03)	0.92
NYHA functional class	1.69	(1.29–2.20)	<0.001	1.89	(1.39–2.56)	<0.001	1.12	(0.62–2.03)	0.70
Diabetes	1.33	(0.97–1.81)	0.07	1.14	(0.94–2.17)	0.51	2.00	(1.35–5.10)	0.02
BMI	0.99	(0.96–1.61)	0.60	0.92	(0.86–0.98)	0.007	1.04	(0.96–1.13)	0.32
β‐Blockers	0.45	(0.30–0.68)	<0.001	0.51	(0.31–0.85)	0.009	0.37	(0.16–0.83)	0.02
ACEI or ARB	0.44	(0.30–0.65)	<0.001	0.41	(0.26–0.64)	<0.001	0.51	(0.21–1.24)	0.26
MRA	0.75	(0.55–1.03)	0.07	0.79	(0.55–1.14)	0.20	0.71	(0.39–1.29)	0.26

ACEI indicates angiotensin‐converting enzyme inhibitor; ARB, angiotensin II receptor blocker; BMI, body mass index; HF, heart failure; HR, hazard ratio; LVEF, left ventricular ejection fraction; MRA, mineralocorticoid receptor antagonist; NYHA, New York Heart Association.

^aPer 1 SD decrease in weight.