Table 6.

Associations Between Presence of Subclinical Coronary Atherosclerosis and Long‐Term ART Use (≥36 Months) in the HIV Infected by Cocaine Use Status (ART Naïve as the Reference Group)

Outcome Variable	Never Cocaine Use						Chronic Cocaine Use
	Unadjusted		Adjusted for ACC/AHA Riska		Adjusted for Propensity Scoreb		Unadjusted		Adjusted for ACC/AHA Riska		Adjusted for Propensity Scoreb
	PR (95% CI)	P Value	PR (95% CI)	P Value	PR (95% CI)	P Value	PR (95% CI)	P Value	PR (95% CI)	P Value	PR (95% CI)	P Value
All subjects (N=679)
Presence of CAC	1.56 (1.07, 2.27)	0.020	1.39 (0.95, 2.03)	0.09	1.08 (0.87, 1.35)	0.47	1.99 (1.34, 2.91)	0.0006	1.88 (1.27, 2.78)	0.002	1.45 (0.98, 2.15)	0.06
Contrast‐enhanced CTA (N=559)
Any coronary plaque	1.48 (1.05, 2.10)	0.025	1.31 (0.93, 1.85)	0.12	1.13 (0.84, 1.35)	0.60	2.07 (1.48, 2.91)	<0.0001	1.95 (1.40, 2.73)	<0.0001	1.87 (1.19, 2.94)	0.007
Noncalcified plaque	1.41 (0.91, 2.18)	0.12	1.26 (0.81, 1.95)	0.31	1.07 (0.79, 1.45)	0.65	2.22 (1.46, 3.39)	0.0002	2.08 (1.37, 3.17)	0.0006	2.46 (1.30, 4.66)	0.006
Calcified plaque	1.53 (1.03, 2.29)	0.037	1.36 (0.91, 2.03)	0.14	1.17 (0.90, 1.53)	0.25	2.03 (1.36, 3.04)	0.0005	1.90 (1.27, 2.83)	0.002	1.55 (0.95, 2.51)	0.07
Coronary stenosis (>50%)	1.37 (0.65, 2.90)	0.41	1.26 (0.60, 2.71)	0.53	1.44 (0.88, 2.31)	0.15	1.89 (0.88, 4.04)	0.10	1.82 (0.85, 3.92)	0.12	1.35 (0.45, 4.05)	0.60
Subclinical CAD	1.37 (1.02, 1.83)	0.035	1.23 (0.93, 1.64)	0.15	1.04 (0.85, 1.27)	0.67	1.87 (1.40, 2.49)	<0.0001	1.79 (1.35, 2.38)	<0.0001	1.62 (1.17, 2.35)	0.011

ACC indicates American College of Cardiology; AHA, American Heart Association; ART, antiretroviral therapy; CAC, coronary artery calcium; subclinical CAD, either presence of CAC and/or any coronary stenosis; CTA, computed tomography angiography; PR, prevalence ratio.

^aAdjusted for cardiovascular risk defined by the 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk.

^bAdjusted for propensity score.