Table 4.
Relative Risk for Mortality During the 4‐Year Follow‐up Stratified by On‐Admission Serum Sodium Level and Change of Serum Sodium Level During Hospitalization
| Group | Cases/Deaths | Model 1 | Model 2 | Model 3 | Model 4 |
|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||
| 1 | 608/233 | 1 | 1 | 1 | 1 |
| 2 | 987/443 | 1.21 (1.03–1.42) | 1.24 (1.06–1.45) | 1.32 (1.07–1.62) | 0.94 (0.48–1.84) |
| 3 | 221/110 | 1.55 (1.24–1.95) | 1.51 (1.20–1.89) | 1.55 (1.15–2.10) | 2.31 (1.02–5.22) |
| 4 | 64/38 | 2.45 (1.72–3.48) | 2.49 (1.97–3.54) | 2.26 (1.36–3.74) | 7.79 (2.29–26.56) |
Model 1: crude ratio; model 2: adjust for age and sex; model 3: adjust for age, sex, hematocrit, estimated glomerular filtration rate, left ventricle ejection fraction, use of beta‐blocker, renin angiotensin system blockade, and spironolactone; model 4: model 3+NT‐proBNP (n=947); group 1=normonatremia on admission without any drop of serum sodium level during hospitalization; group 2=normonatremia on admission with a drop of serum sodium level during hospitalization; group 3=hyponatremia on admission without any drop of serum sodium level during hospitalization; group 4=hyponatremia on admission with a drop of serum sodium level during hospitalization.