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. 2016 Mar 29;5(3):e002681. doi: 10.1161/JAHA.115.002681

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© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Simplified representation of metabolic pathways potentially involved in diastolic LV dysfunction. Metabolites significantly associated with diastolic LV function are in red color. Depicted cycles are (A) glycolysis; (B) citric acid (Krebs) cycle; (C) biopterin cycle; (D) 5‐methylthioadenosine/methionine cycle; (E) transsulfuration (taurine); and (F) methylation (phosphatdylcholine). BH2 and BH4 indicate dihydrobiopterin and tetrahydrobiopterin, respectively; CoA, coenzyme A; LV, left ventricular.