Table 6.

Multivariable‐Adjusted Associations of Tissue Doppler indexes With Metabolites

Metabolic Markers (SD)	Estimate (95% CI)	P B Value
Tyrosine (0.327)
a’ peak	−0.225 (−0.419, −0.030)	0.009
e’/a’	0.054 (0.010, 0.099)	0.004
HDL apolipoproteins (6.689)
a’ peak	−0.229 (−0.425, −0.034)	0.004
e’/a’	0.050 (0.005, 0.095)	0.013
Glucose+taurine (1.209)
e’ peak	0.250 (0.005, 0.496)	0.044
Phosphocholine (1.091)
e’ peak	0.255 (0.003, 0.507)	0.044
Glucose+2‐aminobutyrate (0.616)
a’ peak	−0.261 (−0.509, −0.014)	0.026
Glucose+glutamine (0.552)
a’ peak	−0.277 (−0.483, −0.070)	0.0007
e’/a’	0.049 (0.001, 0.097)	0.035
Glucose+2‐phosphoglycerate (0.131)
a’ peak	−0.209 (−0.407, −0.010)	0.031
Unknown molecule (0.307)
a’ peak	−0.203 (−0.404, −0.002)	0.048
e’/a’	0.047 (0.001, 0.093)	0.044

All estimates were adjusted for sex, age, body mass index, mean arterial pressure, heart rate, total cholesterol, γ‐glutamyltransferase, plasma glucose, LV mass index, and treatment with diuretics, β‐blockers, and inhibitors of the renin‐angiotensin system. Estimates express the change in the dependent variable for a 1‐SD increase in circulating metabolites. P values and 95% CIs account for testing 44 metabolites according to the Bonferroni approach. HDL indicates high‐density lipoprotein; LV, left ventricular.