Table 7.
Factor Loadings of the Metabolic Biomarkers in Analyses Contrasting Normal With Diastolic LV Dysfunction
| Metabolic Biomarker | LF1 | LF2 | LF3 |
|---|---|---|---|
| Amino acids | |||
| 2‐Aminobutyrate | −0.25 | 0.13 | −0.10 |
| 4‐Aminobutyrate | −0.23 | 0.16 | −0.14 |
| Alanine | −0.26 | 0.04 | −0.03 |
| Aspartate | −0.02 | 0.15 | −0.27 |
| Glutamate | −0.13 | 0.15 | −0.26 |
| Glycine | −0.07 | 0.23 | −0.01 |
| Glutamine | −0.13 | 0.16 | −0.27 |
| Isoleucine | −0.11 | −0.11 | 0.12 |
| Leucine | −0.24 | 0.13 | −0.12 |
| Phenylalanine | −0.01 | 0.16 | −0.26 |
| Threonine | −0.08 | 0.26 | 0.02 |
| Tyrosine | −0.15 | 0.06 | −0.05 |
| Valine | −0.18 | −0.13 | 0.13 |
| Lipids | |||
| Fatty acid with α‐CH2 | 0.21 | 0.01 | −0.21 |
| Fatty acid with (‐CH2‐)n | 0.12 | −0.21 | 0.14 |
| Fatty acid with =CH‐CH2‐CH2= +citrate | 0.01 | 0.14 | −0.23 |
| Fatty acid with –CH3 | −0.03 | −0.19 | 0.24 |
| Fatty acid with =CH‐CH2‐CH2‐ | 0.05 | −0.18 | 0.10 |
| Fatty acid with –CH=CH | 0.24 | −0.07 | −0.07 |
| HDL apolipoproteins | −0.15 | 0.08 | −0.08 |
| Cholesterol | −0.08 | −0.12 | 0.27 |
| Valerate | 0.31 | −0.10 | −0.05 |
| Fatty acid with β‐CH2 | 0.05 | −0.02 | −0.22 |
| 3‐Hydroxybutyrate | −0.01 | −0.13 | 0.25 |
| Carbohydrates | |||
| α‐glucose | 0.11 | 0.07 | 0.05 |
| Glucose+taurine | −0.06 | 0.05 | −0.07 |
| Glucose | −0.04 | 0.26 | −0.02 |
| Glycoprotein | 0.19 | 0.09 | −0.04 |
| Organic acids | |||
| Acetate | −0.25 | 0.08 | 0.06 |
| 4‐Hydroxybutyrate | −0.25 | 0.10 | −0.13 |
| Lactate | 0.28 | −0.03 | −0.12 |
| 2‐Oxobutyrate | 0.13 | 0.08 | −0.23 |
| Other metabolites | |||
| Creatinine | 0.01 | 0.15 | −0.24 |
| Choline | −0.06 | 0.03 | 0.04 |
| Ethanolamine | −0.10 | 0.16 | −0.08 |
| Trimethylamine | −0.01 | 0.14 | −0.18 |
| Glycerol | −0.09 | 0.16 | −0.04 |
| Ethanol | −0.14 | 0.14 | 0.12 |
| Creatine+creatine‐phosphate | −0.15 | 0.21 | −0.14 |
| Phosphocholine | −0.14 | −0.08 | −0.01 |
| Glucose+2‐aminobutyrate | −0.03 | 0.23 | 0.12 |
| Glucose+glutamine | −0.10 | 0.28 | 0.02 |
| Glucose+2‐phosphoglycerate | −0.13 | 0.24 | 0.09 |
| Unknown molecule | −0.14 | 0.22 | 0.06 |
The study population was dichotomized in 538 participants with normal LV function and 173 with subclinical diastolic LV dysfunction.4, 5 LF1, LF2, and LF3 refer to the first, second, and third latent factors derived by partial least square discriminant analysis of 44 metabolites. LV indicates left ventricular.