Table 3.
Variables | Age‐, Sex‐ and Cohort‐ Adjusted | Multivariable Adjusteda | ECG×Cohort | ECG×Sex | ||
---|---|---|---|---|---|---|
HR (95% CI) | P Value | HR (95% CI) | P Value | Interaction P | Interaction P | |
PR interval | 1.03 (0.97, 1.09) | 0.35 | 1.07 (1.01, 1.13) | 0.03 | 0.79 | 0.48 |
QRS duration | 1.09 (1.04, 1.15) | 0.001 | 1.09 (1.03, 1.15) | 0.003 | 0.49 | 0.67 |
QT interval | 1.04 (0.97, 1.10) | 0.26 | 1.25 (1.15, 1.36) | <0.0001 | 0.53 | 0.44 |
QTcFram | 1.15 (1.09, 1.22) | <0.0001 | 1.15 (1.08, 1.22) | <0.0001 | 0.98 | 0.01 |
QTcBaz | 1.20 (1.13, 1.27) | <0.0001 | 1.18 (1.11, 1.25) | <0.0001 | 0.56 | 0.004 |
QRS voltage | 1.15 (1.08, 1.23) | <0.0001 | 1.12 (1.05, 1.20) | 0.0009 | 0.045 | 0.28 |
LVH | 1.93 (1.49, 2.50) | <0.0001 | 1.73 (1.33, 2.24) | <0.0001 | 0.02 | 0.14 |
Left atrial enlargement | 1.58 (1.26, 1.99) | <0.0001 | 1.41 (1.12, 1.77) | 0.004 | 0.06 | 0.91 |
LBBB | 1.41 (0.87, 2.28) | 0.16 | 1.35 (0.83, 2.18) | 0.2 | 0.68 | 0.91 |
RBBB | 1.29 (0.99, 1.68) | 0.06 | 1.21 (0.93, 1.58) | 0.2 | 0.64 | 0.90 |
Hazard ratio is per SD change in continuous variables, and from comparison of the presence of dichotomous variables to their absence. CI indicates confidence interval; ECG, electrocardiogram; HR, hazard ratio; LBBB, left bundle branch block; LVH, left ventricular hypertrophy; RBBB, right bundle branch block.
Adjusted for body mass index, heart rate (except QTc), systolic blood pressure, antihypertensive therapy, diabetes, and smoking.