Table 6.
SD and Coefficient of Variation of Home Blood Pressure at Baseline and After the Monotherapy Among 3 Drug Classes
| Characteristic | Calcium Channel Blocker | Angiotensin‐Converting Enzyme Inhibitor | Angiotensin Receptor Blocker | Crude P Value | Adjusted P Value |
|---|---|---|---|---|---|
| At baseline | |||||
| SD, mm Hg | |||||
| Morning systolic | 8.80 (4.12) | 9.40 (4.52) | 9.27 (4.43) | 0.019 | 0.0009 |
| Morning diastolic | 5.07 (2.45) | 5.04 (2.58) | 5.22 (2.70) | 0.32 | 0.28 |
| Evening systolic | 10.71 (4.75) | 10.71 (4.84) | 11.01 (5.25) | 0.62 | 0.26 |
| Evening diastolic | 6.38 (3.04) | 6.42 (3.13) | 6.52 (3.12) | 0.66 | 0.31 |
| Coefficient of variation, % | |||||
| Morning systolic | 5.81 (2.68) | 6.21 (2.89) | 6.16 (2.90) | 0.0090 | 0.0017 |
| Morning diastolic | 5.68 (2.77) | 5.69 (3.06) | 5.91 (3.18) | 0.27 | 0.21 |
| Evening systolic | 7.48 (3.31) | 7.50 (3.37) | 7.72 (3.74) | 0.68 | 0.25 |
| Evening diastolic | 7.75 (3.63) | 7.85 (3.80) | 8.01 (3.92) | 0.55 | 0.21 |
| After monotherapy | |||||
| Δ SD, mm Hg | |||||
| Morning systolic | 0.19 (5.17) | 0.09 (5.78) | 0.34 (5.48) | 0.80 | 0.0084 |
| Morning diastolic | 0.15 (3.06) | −0.12 (3.25) | 0.01 (3.11) | 0.11 | 0.060 |
| Evening systolic | 0.72 (6.05) | 0.31 (6.11) | 0.54 (6.19) | 0.32 | 0.085 |
| Evening diastolic | 0.29 (3.76) | 0.06 (3.74) | 0.21 (3.64) | 0.31 | 0.11 |
| Δ Coefficient of variation, % | |||||
| Morning systolic | −0.21 (3.51) | −0.15 (3.89) | −0.15 (3.79) | 0.81 | 0.078 |
| Morning diastolic | −0.08 (3.50) | −0.31 (3.82) | −0.28 (3.64) | 0.18 | 0.043 |
| Evening systolic | 0.05 (4.28) | −0.15 (4.38) | −0.10 (4.45) | 0.50 | 0.12 |
| Evening diastolic | −0.05 (4.61) | −0.30 (4.67) | −0.17 (4.62) | 0.35 | 0.12 |
Values are arithmetic mean (SD). Crude P denotes the significance of the difference among drug classes, and adjusted P displays the significance which accounts for sex, age, body mass index, corresponding blood pressure level, variability, and heart rate at baseline, current smoking and drinking, hypercholesterolemia, diabetes mellitus, history of cardiovascular disease, and defined daily doses.