Table 7.
Baseline Blood Pressure Level and Variability and Reduction of These Indexes After Monotherapy Among Patients With Amlodipine or Other CCB
| Characteristic | Amlodipine (n=439) | Other CCB (n=394) | Crude P Value | Adjusted P Value |
|---|---|---|---|---|
| Baseline measurement | ||||
| Home blood pressure, mm Hg | ||||
| Morning systolic | 152.9 (12.3) | 150.1 (12.7) | 0.0004 | <0.0001 |
| Morning diastolic | 90.8 (9.6) | 88.9 (9.7) | 0.0016 | 0.0001 |
| Evening systolic | 145.1 (15.0) | 143.0 (15.6) | 0.058 | 0.0023 |
| Evening diastolic | 83.5 (10.6) | 82.0 (10.7) | 0.039 | 0.0061 |
| Home VIM, U | ||||
| Morning systolic | 8.67 (4.24) | 8.90 (3.82) | 0.16 | 0.39 |
| Morning diastolic | 5.05 (2.43) | 5.09 (2.45) | 0.72 | 0.036 |
| Evening systolic | 10.52 (4.47) | 10.92 (4.95) | 0.33 | <0.0001 |
| Evening diastolic | 6.34 (2.74) | 6.42 (3.24) | 0.77 | <0.0001 |
| Home ARV, mm Hg | ||||
| Morning systolic | 10.04 (5.26) | 9.99 (4.77) | 0.83 | 0.090 |
| Morning diastolic | 5.75 (3.03) | 5.81 (3.07) | 0.68 | 0.0053 |
| Evening systolic | 12.48 (5.93) | 12.84 (6.75) | 0.80 | 0.0006 |
| Evening diastolic | 7.46 (3.69) | 7.55 (4.42) | 0.54 | <0.0001 |
| After the monotherapy | ||||
| Δ Home blood pressure, mm Hg | ||||
| Morning systolic | 10.24 (10.63) | 6.03 (10.26) | <0.0001 | <0.0001 |
| Morning diastolic | 5.00 (6.27) | 2.67 (5.78) | <0.0001 | <0.0001 |
| Evening systolic | 11.27 (11.75) | 7.36 (11.27) | <0.0001 | <0.0001 |
| Evening diastolic | 5.39 (6.61) | 3.52 (6.69) | <0.0001 | <0.0001 |
| Δ Home VIM, U | ||||
| Morning systolic | 0.35 (5.18) | −0.14 (5.16) | 0.30 | 0.018 |
| Morning diastolic | 0.23 (2.90) | 0.05 (3.21) | 0.54 | 0.29 |
| Evening systolic | 0.52 (5.90) | 0.89 (6.01) | 0.80 | 0.63 |
| Evening diastolic | 0.27 (3.60) | 0.32 (3.82) | 0.92 | 0.92 |
| Δ Home ARV, mm Hg | ||||
| Morning systolic | 0.44 (6.63) | −0.65 (6.56) | 0.035 | 0.0023 |
| Morning diastolic | 0.32 (3.74) | 0.09 (4.01) | 0.62 | 0.19 |
| Evening systolic | 0.69 (8.11) | 0.84 (8.47) | 0.68 | 0.89 |
| Evening diastolic | 0.37 (4.74) | 0.28 (5.35) | 0.51 | 0.51 |
Values are arithmetic mean (SD). Crude P denotes the significance of the difference between amlodipine and other CCBs, and adjusted P displays the significance which accounts for sex, age, body mass index, corresponding blood pressure level (for VIM and ARV) or variability (for level) at baseline, corresponding heart rate at baseline, current smoking and drinking, hypercholesterolemia, diabetes mellitus, history of cardiovascular disease, and defined daily doses. ARV indicates average real variability; CCB, calcium channel blocker; VIM, variability independent of the mean.