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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Clin Cancer Res. 2016 Apr 15;22(8):1845–1855. doi: 10.1158/1078-0432.CCR-16-0049

Figure 2. Concept of immune mediated abscopal effects.

Figure 2

Schematic representation of immune mediated effects. The scheme describes the systemic pro-inflamatory effects of gamma irradiation of the irradiated tumor lesion well that become hot and acts as an in situ tumor-attenuated vaccine against distant non-irradiated tumors. Such local response can be enhanced by immunostimulatory monoclonal antibodies to attain a systemic effect. Exploiting the systemic immune-mediated effects of radiotherapy offers opportunity to maximize the effect of novel immunotherapies. DC, dendritic cell; CTL, cytotoxic T cell.