. Author manuscript; available in PMC: 2016 Jul 13.

Published in final edited form as: Curr Med Chem. 2011;18(30):4659–4673. doi: 10.2174/092986711797379267

TABLE 2.

Jak2 Chromosomal Translocations

TRANSLOCATION	FUSION PARTNER	DISEASE	REFERENCE
t(9;12)(p24;p13)	TEL-Jak2	T-ALL, precursor B-ALL, atypical CML, MDS	[52,53,66]
t(9;22)(p24;q11.2), t(9;22)(p24;q11)	BCR-Jak2	atypical CML, AML	[54,55]
t(8;9)(p22;p24)	PCM1-Jak2	atypical CML, precursor B-ALL, CEL, AML, T-cell lymphoma, PMF, MDS/MPN	[56–59]
del(9)(p13:p24)	PAX5^b	ALL	[60–61]
t(5;9)(p14.1;p24.1)	SSBP2	precursor B-ALL	[64]
t(4;9)(q21;p24)	SEC31A-Jak2	classical Hodgkin Lymphoma (cHL)	[65]
t(9;12)(p24;q13)	NFE2^c	MDS	[66]
add (9) (p24) and del (21)(q11.2)	AML1 (RUNX1)^c	MDS	[66]
t(3;9)(q21;p24)	RPN1 ^c	CIMF	[67]
t(9;22)(p24;q11.2)	Unknown	B-ALL	[68]
t(2;9)(p21;p24)	Unknown	PMF	[69]
t(8;9)(q22;p24)	Unknown	PMF	[69]
t(9;17)(p24;q23)	Unknown	PV	[69]
t(4;9)(q25;p24)	Unknown	PMF	[69]
t(8;9)(q13;p24)	Unknown	DLBCL	[69]

Abbreviations: AML1 - acute myeloid leukemia 1, BCR - B-cell receptor, CML - chronic myeloid leukemia, CEL - chronic eosinophilic leukemia, cHL - classic hodgkin’s lymphoma, CIMF - chronic idiopathic myelofibrosis, DLBCL - diffuse large B-cell lymphoma, ETV6 - Ets variant gene 6, NFE2 - nuclear factor erythroid-derived 2, PAX5 - paired box gene 5, PCM1 - Human autoantigen pericentriolar material 1, PMF - primary myelofibrosis, PV - polycythemia vera, RPN1 - ribophorin 1, SSBP2 - single stranded DNA binding protein 2, T-ALL - T cell ALL.

PAX5-Jak2 is not constitutively active.

Not fully characterized