Skip to main content
. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: Curr Med Chem. 2011;18(30):4659–4673. doi: 10.2174/092986711797379267

TABLE 3.

Current allosteric inhibitors for BCR-ABL and Jak2 that target sites other than the ATP-binding site

NAME STRUCTURE TARGET KINASES IC50 (nM) PREDICTED MECHANISM OF INHIBITION REF.
GNF-2 graphic file with name nihms460595t1.jpg BCR-ABL 138 Targets the myristoyl binding cleft [79]
DCC-2036 graphic file with name nihms460595t2.jpg BCR-ABL 5.8 Targets the switch control pocket [80]
ON012380 graphic file with name nihms460595t3.jpg BCR-ABL 10 Substrate-competitive [81]
LS104 graphic file with name nihms460595t4.jpg Jak2, FLT3 1500 (Jak2), 4000 (FLT3) Substrate-competitive [87,88]
ON044580 graphic file with name nihms460595t5.jpg BCR-ABL, Jak2 3000 (BCR- ABL), 4000 (Jak2) Substrate-competitive [89]