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. Author manuscript; available in PMC: 2016 Jul 13.

Published in final edited form as: Mol Pharm. 2015 May 6;12(8):2665–2674. doi: 10.1021/acs.molpharmaceut.5b00062

Table 3.

Pharmacokinetic parameters of vancomycin dry powder following i.v. and pulmonary drug administration (values = average ± S.D., n = 3).

PK parameters	Subject
PK parameters	1 mg/kg I.V.	1 mg/kg Inhaled	5 mg/kg Inhaled
Terminal Slope (1/hr)	0.2073 ± 0.0282	0.2244 ± 0.0272	0.2369 ± 0.0208
Half-Life (hr)	3.38 ± 0.43	3.12 ± 0.40	2.94 ± 0.25
T_max (hr)	0.67 ± 0.29	2.00 ± 0.00	2.67 ± 1.15
C_max (ng/mL)	3330 ± 1119	1697 ± 337	6917 ± 724
C₀ (ng/mL)	5347 ± 4927	N/A	N/A
*AUC_last (hrng/mL)**	12069.85 ± 638.15	16066.85 ± 2877.14	67100.93 ± 4552.18
*AUC_(0-∞) (hrng/mL)**	12135.34 ± 616.52	16135.36 ± 2840.68	67304.80 ± 4482.83
Volume of Dist. (mL/kg)	403.89 ± 64.83	289.64 ± 91.54	316.87 ± 42.58
Clearance (mL/hr/kg)	82.55 ± 4.25	63.33 ± 11.60	74.50 ± 4.93