Fig. 7.

Dissolution models are shown and how they best represent the dissolution of micronized stock and NanoClusters. Models included are the classical Higuchi in dotted gray and late time approximation based on the Peppas and Siepmann modified Higuchi model in dotted black as macroscopic models. Also included are microscopic models of micronized drug in solid gray and Nanocrystal® in solid black. Included in gray squares is the micronized stock data and in black squares is the NanoCluster data.