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. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: J Pharm Sci. 2014 Apr 30;103(6):1787–1798. doi: 10.1002/jps.23980

Table 2.

Danazol powder characteristics including percent degradation, particle sizing from DLS, D50 from MFI, BET surface area, and DSC melting temperature.

Sample Degradation Particle Size NanoCluster D50 Size BET Surface Area DSC Melting Temperature
Stock Danazol - 2.5 um* 2.5 um 3.28±0.03 m2/g 227.49 ºC
5 Hour Milled 0.39±0.20% 341.2±8.6 nm 2.0 um 25.86±0.10 m2/g 223.82 ºC
10 Hour Milled 0.90±0.48% 354.5±10.0 nm 1.8 um 36.75±0.14 m2/g 222.08 ºC
15 Hour Milled 1.23±0.06% 412.8±11.8 nm 1.6 um 47.65±0.26 m2/g 220.89 ºC
Nanoparticle Suspension - 234.8±1.9 nm - 34.07 m2/g** 224.78 ºC
*

Calculated from BET;

**

Calculated from particle size45

Particle size was determined using DLS while MFI was used to determine NanoCluster D50 size.