TABLE IV.
Antibacterial Activity of Bromotyrosine Derivatives.
| Alkaloids | Antimicrobial activitya | Ref. |
|---|---|---|
| 3-Bromoverongiaquinol (10) | Active against S. f., B. s.; not active against A. f., P. v. | 9 |
| 3-Bromo-5-chloroverongiaquinol (11) | Active against S. l., A. f., P. v. | 9 |
| (–)-Aeroplysinin-1 (17) | MIC 20–100 μg/mL against S. a., B. s., M. l., E. c., P. a. | 16 |
| (+)-Aeroplysinin-1 (14) | MIC 20–100 μg/mL against S. a., B. s., M. l., E. c., P. a. | 16 |
| 31 | ||
| 7-Bromocavernicolenone (30) | Active against P. c.; not active against B. s. | 24 |
| 38 | 3000 μg/disk shows inhibition zone against E. c. 18–22 mm | 31 |
| Aeroplysinin-2 (18) | 3000 μg/disk shows inhibition zone against E. c. <15 mm | 31 |
| Moloka'iamine (52) | Inhibit the growth of B. m., P. n., A. m., V. a., F. m. at 10 μg /disk | 49 |
| Aplysamine-1 (54) | Not active against S. a., B. s., S. l., E. c., S. sp. | 44 |
| Aplysamine 2 (172) | Not active against S. a., B. s., S. l., E. c., S. sp. | 44 |
| Ceratinamine (60) | Inhibit the growth of B. m., P. n., A. m., V. a., F. m. at 10 μg/disk | 49 |
| Aerothionin (68) | Inhibit the growth of S. a. at 100 μg/disk, B. s. at 50 μg/disk | 63 |
| Homoaerothionin (69) | Inhibit the growth of S. a. at 100 μg/disk, B. s. at 50 μg/disk | 63 |
| 11,19-Dideoxy-fistularin 3 (83) | Inhibit the growth of S. a. at 25 μg/disk, B. s. at 10 μg/disk | 63 |
| 11-Hydroxyaerothionin (71) | Inhibit the growth of S. a. at 100 μg/disk, B. s. at 50 μg/disk | 63 |
| 11-Oxoaerothionin (72) | MIC 30 μg/mL against S. a., P. a.; 10 μg/mL against E. c. | 64 |
| 11-Epi-fistularin-3 (81) | Active against B. s., M. l.; not active against E. c. | 70 |
| Agelorin A (87) | Active against B. s., M. l.; not active against E. c. | 70 |
| Agelorin B (88) | Active against B. s., M. l.; not active against E. c. | 70 |
| Zamamistatin (91) | Active against R. s. | 75 |
| Aplysinamisine I (120) | Inhibit the growth of S. a., E. c., P. a. at 50–100 μg/disk | 83 |
| Aplysinamisine II (124) | Inhibit the growth of S. a., E. c., P. a. at 50–100 μg/disk | 83 |
| Aplysinamisine III (102) | Inhibit the growth of S. a., E. c., P. a. at 50–100 μg/disk | 83 |
| Purealidin B (109) | MIC 62.5 μg/mL against S. a., 15.6 μg/mL against B. s., 3.9 μg/mL against S. l. | 84 |
| Purealidin C (192) | MIC 62.5 μg/mL against S. a., 15.6 μg/mL against S. l. | 84 |
| Araplysillin-I (99) | 250 μg/disk shows inhibition zone against S. a. 12 mm | 81 |
| Araplysillin-II (100) | 250 μg/disk shows inhibition zone against S. a. 7 mm | 81 |
| Anomoian A (195) | Inhibit the growth of S. a. at 10 μg/disk, B. s. at 5 μg/disk | 124 |
| Bromochelonin B (257) | Inhibit the growth of B. s. at 100 μg/disk | 154 |
| Purpuramine K (190) | 25 μg/disk shows inhibition zone against S. a. 10, P. a. 10; B. s. 8; C. v. 7; K. a. 10 mm | 122 |
| Purpuramine L (191) | 25 μg/disk shows inhibition zone against S. a., B. s. 14; P. a. 16; B. sp 12 mm | 122 |
| Psammaplin A (152) | Active against S. a., B. s. | 109 |
| Bisaprasin (154) | Active against S. a., B. s. | 109 |
| Psammaplin D (158) | Inhibit the growth of S. a., T. m. at 100 μg/disk. | 110 |
| Bastadin-1 (204) | MIC: S. a. 6.25–12.5, E. c. 100, N. g. 50–100, E. f. 12.5–25 μg/disk | 41 |
| Bastadin-2 (205) | MIC: S. a. 6.25–12.5, N. g. 50–100, E. f. 50–100 μg/disk | 41 |
| Bastadin-3 (206) | MIC: S. a. 1.56–3.12, N. g. 0.78–1.56, E. f. 3.12–6.25 μg/disk | 41 |
| Bastadin-4 (208) | MIC: S. a. 12.5–25, N. g. 12.5–25, E. f. 50–100 μg/disk | 41 |
| Bastadin-5 (209) | MIC: S. a. 12.5–25, N. g. 50–100, E. f. 50–100 μg/disk | 41 |
| Bastadin-6 (210) | MIC: S. a. 6.25–12.5, E. f. 12.5–25 μg/disk | 41 |
| 207 | MIC: N. g. 50–100 μg/disk | 41 |
| Hemibastadin 1 (231) | MIC: S. a. 1.56–3.12, N. g. 12.5–25, E. f. 50–100 μg/disk | 41 |
| 1′-(Methyloxy) hemibastadins 1 (237) | MIC: S. a. 6.25–12.5, N. g. 6.25–12.5 μg/disk | 41 |
| Hemibastadins 2 and 3 (232, 233) | MIC: S. a. 6.25–12.5, N. g. 6.25–12.5, E. f. 50–100 μg/disk | 41 |
| Hemibastadinol 1 (234) | MIC: N. g. 50–100 μg/disk | 41 |
| Hemibastadinols 2 and 3 (235, 236) | MIC: N. g. 50–100 μg/disk | 41 |
| Bastadin-13 (217) | MIC 6 μg/mL against B. s. | 41 |
a
Streptococcus faecalis (S. f.); Staphylococcus aureus (S. a.); Bacillus subtilis (B. s.); Micrococcus luteus (M. l.); Sarcina lutea (S. l.); Bacillus marinus (B. m.); Bacillus sphaericus (B. sp.). Escherichia coli (E. c.); Pseudomonas aeruginosa (P. a.); Neisseria gonorrhoeae (N. g.); Alcaligena faecalis (A. f.); Chromobacterium violaceum (C. v.); Klebsiella aerogenes (K. a.); Proteus vulgaris (P. v.); Vibrio alginolyticus (V. a.); Pseudomonas cichorii (P. c.); Pseudomonas nautical (P. n.); Alteromonas macleodii (A. m.); Flavobacterium marinotypicum (F. m.); Rhodospirillum salexigens (R. s.); Serratia sp. (S. sp.); Escherichia faecalis (E. f.).