TABLE IX.
Enzyme Activity of Some Bromotyrosine Derivatives.
| Alkaloids | Activity (IC50) |
Ref. | ||||
|---|---|---|---|---|---|---|
| Tyrosine kinase (mM) | Na,K-ATPase | Myosin K,EDTA-ATPase | Farnesyl protein transferase | AP-N (mM) | ||
| Psammaplin D (158) | 2.8 | 110 | ||||
| Purealidin A (146) | 22% Inhibition at 10−4M | – | 104 | |||
| Purealin (122) | Activate | 91 | ||||
| Lipopurealin-A (141) | 30 M (brain) 20 M (kidney) 100 M (heart) |
102 | ||||
| Lipopurealin-B (142) | 6 M (brain) 10 M (kidney) > 100 M (heart) |
Inhibit | 102 | |||
| Lipopurealin-C (143) | 60 M (brain) 20 M (kidney) > 100 M (heart) |
102 | ||||
| Araplysillin-I (99) | 0.5 mM (brain) | 81 | ||||
| Araplysillin-II (100) | 1 mM (brain) | 81 | ||||
| Psammaplin A (152) | 7.0 mM | 70.9 | 114 | |||
| Bisaprasin (154) | 4.2 mM | 30.2 | 114 | |||
| Psammaplin A1 (165) | 3.0 mM | 114 | ||||
| Psammaplin A2 (166) | 4.4 mM | 114 | ||||
| Aplysinellin A (167) | 85.2 mM | 2.4 | 114 | |||
| Aplysinellin B (168) | 25.1 mM | 114 | ||||