FIG. 10.

Treatment of SW480 in coculture with fibroblasts with 25 μM 5-FU under static as well as dynamic conditions. Under static culture conditions (A, B), treatment with 5-FU results in decreased tumor cell numbers (green) but leaves fibroblasts (red) unaffected (B). The same effect can be seen under dynamic conditions (C, D) where tumor cell numbers are much higher in the untreated control (C) compared to the treated sample (D). Scale bar in D: 100 μm for (A–D). PCK: green, vimentin: red, DAPI: blue. 5-FU, 5-fluorouracil. Color images available online at www.liebertpub.com/tec