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. 2016 Jun 2;22(7):621–635. doi: 10.1089/ten.tec.2015.0557

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© Sarah Nietzer et al., 2016; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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FIG. 8. — The 3D colon cancer model with integrated fibroblasts phenocopies a patient's colon adenocarcinoma. PCK (green) and vimentin (red) fluorescence double staining demonstrates a close association of SW480 tumor cells (PCK positive) with cocultured fibroblasts (vimentin positive) in a dynamic bioreactor culture. This phenotype reflects the morphology of a colon adenocarcinoma from a patient's biopsy (C). Scale bars: 50 μm in (A, C) and 100 μm in (B). Color images available online at www.liebertpub.com/tec