Table 2.

Contribution of Nongenetic Factors to Risk of Low-trauma Fractures in Univariable and Multivariable Analyses, Odds Ratio (95% Confidence Interval)

Variable	Univariable Analysis	P Value	Multivariable Analysis Without Genetic Background	P Value
Age, per additional year	1.04 (1.02–1.06)	<.01	1.02 (1.00–1.04)	.06
Current/past smoking	0.98 (0.97–1.00)	.07	0.58 (0.38–0.90)	.02
≥3 units alcohol/day	1.01 (0.99–1.02)	.38	1.11 (0.77–1.62)	.57
Weight, per additional kg	0.99 (0.98–1.04)	.15	1.00 (0.98–1.01)	.81
Height, per additional cm	0.94 (0.91–0.96)	<.01	0.95 (0.92–0.98)	<.01
Hepatitis C coinfection	0.86 (0.58–1.29)	.49	1.16 (0.68–1.96)	.59
Injection drug use	0.68 (0.46–1.01)	.06	0.86 (0.49–1.52)	.60
CD4 nadir	1.00 (1.00–1.00)	.95	1.00 (1.00–1.00)	.26
Cumulative tenofovir exposure, per additional year	0.97 (0.90–1.04)	.35	0.97 (0.90–1.05)	.44
Protease inhibitor (with ritonavir) exposure, per additional year	1.01 (0.95–1.07)	.76	1.04 (0.96–1.12)	.35
Protease inhibitor (without ritonavir) exposure, per additional year	1.04 (0.98–1.09)	.20	1.05 (0.99–1.12)	.13
Parental history of hip fracture	1.46 (0.96–2.23)	.08	1.35 (0.84–2.14)	.21
Corticosteroid exposure ≥3 mo	4.15 (2.08–8.24)	<.01	3.12 (1.48–6.58)	<.01

^a Current or past smoking vs never smoking.

^b ≥3 units alcohol/day vs less.