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. 2016 May 12;3(2):ofw096. doi: 10.1093/ofid/ofw096

Table 1.

MSIS and IDSA Criteria for Periprosthetic Joint Infection (PJI)a

  1. Major Criteria
    1. A sinus tract that communicates with the prosthesis
    2. Isolation of a virulent pathogen (eg, Staphylococcus aureus) on 2 separate tissue or fluid culture samples obtained (perioperative aspirate and/or intraoperative) from the affected prosthesis
  1. Minor Criteria
    1. Purulence within the affected joint
    2. Erythrocyte sedimentation rate >30 mm/h and C-reactive protein level >10 mg/L
    3. Synovial fluid leukocyte count >3000 cells/µL
    4. Synovial fluid neutrophil percentage >65%
    5. Isolation of a virulent pathogen on 1 separate tissue or fluid culture sample obtained (perioperative aspirate and/or intraoperative) from the affected prosthesis
    6. Greater than 5 neutrophils per high-powered field in 5 high-powered fields observed on histological analysis of periprosthetic tissue at 400× magnification
  • Definite PJI
    1. One major criterion
    2. Four of 6 minor criteria
  • Possible PJI
    1. The presence of PJI is possible even if the above criteria are not met; the clinician should use his/her clinical judgment to determine whether this is the case after reviewing all the available preoperative and intraoperative information

Abbreviations: IDSA, Infectious Disease Society of American; MSIS, Musculoskeletal Infection Society.

a References [10, 11].