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. 2016 May 23;3(2):ofw108. doi: 10.1093/ofid/ofw108

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© The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 5. — (A) Correlation of immune response measured on day 0 to peak amount of live, attenuated influenza vaccine (LAIV) shed (N = 13, aggregate of 39 strain comparisons). (B) Correlation of the fold-change in LAIV immune responses measured between days 0 and 28 to the amount of virus shed on LAIV challenge (N = 11 prior recipients of LAIV, aggregate of 33 strain comparisons). (C) Correlation of the fold-change in inactivated influenza vaccine immune responses measured between days 0 and 28 to the amount of virus shed on LAIV challenge (N = 15 prior recipients of IIV, aggregate of 45 strain comparisons). (D) Correlation of the fold-change in immune response measured between days 0 and 28 to the decrease in peak virus titer between the first and second doses of LAIV (N = 11 participants, aggregate of 33 strain comparisons). The vertical bar indicates the color associated with the strength of a direct correlation (blue ellipse leaning to the right) or an inverse correlation (red ellipse leaning to the left) correlations. An X through the ellipse indicates that the correlation was not significant. Data represent aggregate immune responses to all 3 influenza virus strains in the vaccine. Abbreviations: ADCC, antibody-dependent cellular cytotoxicity; HAI, hemagglutination inhibition; kELISA, kinetic enzyme-linked immunosorbent assay; MN, microneutralization; NAI, neuraminidase inhibition.