Table 1.

Time to onset and duration of action (mean ± 1 SD) of alfaxalone and ketamine alone and in combination with xylazine in male (n= 8) and female (n= 6) mice

	Time to onset (min)		Duration (min)
	Male	Female	Male	Female
Alfaxalone	2.4 ± 0.5	2.2 ± 0.4	46.0 ± 3.3a	67.0 ± 5.5a,b
Ketamine	5.3 ± 1.7c	5.6 ± 0.9c	8.8 ± 2.2	5.4 ± 1.5
Alfaxalone + xylazine	2.3 ± 0.2	2.3 ± 0.2	73.1 ± 5.6d	89.8 ± 6.6d
Ketamine + xylazine	4.1 ± 0.4e	4.0 ± 0.4e	39.9 ± 3.1	34.2 ± 2.2

^aSignificantly (P < 0.001) greater than corresponding value in ketamine-treated mice of same sex.

^bSignificantly (P = 0.02) greater than corresponding value in alfaxalone-treated male mice.

^cSignificantly (P < 0.001) greater than corresponding value in alfaxalone-treated mice of same sex.

^dSignificantly (P < 0.0001) greater than corresponding value in mice of same sex treated with ketamine and xylazine.

^eSignificantly (P < 0.001) greater than corresponding value in mice of same sex treated with ketamine and xylazine.