Table 4.

Cardiovascular values (mean ± 1 SD; n≥ 12 mice per group) for total AUC above baseline for time until ataxia at various CO₂CRR

	Chamber replacement rate (per minute)
	15%	30%	50%	100%	Pb
Total heart rate (sum of heart beats)a	4632 ± 3195	3104 ± 1606	1476 ± 566	2156 ± 783	0.001
Heart rate (beats per second)a	58.4 ± 38.4	65.2 ± 39.6	46.1 ± 14.0	86.6 ± 23.5	0.04
Total systolic blood pressure (sum of mm Hg)a	1262 ± 621	1131 ± 381	853 ± 308	728 ± 167	0.27
Systolic blood pressure (mm Hg) per second	16.0 ± 7.7	23.2 ± 8.5	27.8 ± 10.9	30.0 ± 7.2	0.007
Total diastolic blood pressure (sum of mm Hg)a	1049 ± 517	879 ± 423	695 ± 302	540 ± 192	0.008
Diastolic blood pressure (mm Hg) per second	13.3 ± 6.3	17.8 ± 8.8	22.7 ± 10.2	22.0 ± 7.9	0.12
Total mean blood pressure (sum of mm Hg)	1131 ± 559	985 ± 389	746 ± 297	636 ± 172	0.08
Mean blood pressure (mm Hg) per second	14.4 ± 6.8	20.1 ± 8.4	24.4 ± 10.2	26.1 ± 6.7	0.02

^aData were transformed for analysis

^bANOVA group significance level