Table 3. Mean BrainAGE scores at baseline and last follow-up for all particular allelic isoforms within the diagnostic groups of the longitudinal sample.
| NO | sMCI | pMCI | AD | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Last follow-up | Baseline | Last follow-up | Baseline | Last follow-up | Baseline | Last follow-up | |
| APOE ε2 / ε3 | ||||||||
| No. subjects | 16 | 3 | 2 | 4 | ||||
| BrainAGE mean (SD) | -2.66 (5.32) | -3.01 (5.42) | +1.95 (6.92) | +2.71 (5.45) | +3.43 (5.29) | +9.24 (2.10) | +8.80 (4.86) | +11.31 (6.16) |
| APOE ε3 / ε3 | ||||||||
| No. subjects | 65 | 19 | 32 | 45 | ||||
| BrainAGE mean (SD) | -1.03 (6.69) | -1.01 (6.18) | -0.21 (4.73) | -1.16 (4.60) | +5.67 9.93) | +7.22 (10.60) | +5.97 (9.82) | +7.35 (10.40) |
| APOE ε2 / ε4 | ||||||||
| No. subjects | 1 | 0 | 5 | 4 | ||||
| BrainAGE mean (SD) | +13.28 (0.00) | +11.72 (0.00) | - | - | +3.39 (6.72) | +7.25 (6.05) | +2.10 (10.60) | +3.29 (7.97) |
| APOE ε3 / ε4 | ||||||||
| No. subjects | 21 | 12 | 52 | 66 | ||||
| BrainAGE mean (SD) | -1.42 (6.44) | -1.28 (8.07) | -0.15 (6.28) | +0.47 (6.45) | +5.38 (5.85) | +7.40 (7.03) | +6.19 (8.74) | +8.45 (8.60) |
| APOE ε4 / ε4 | ||||||||
| No. subjects | 4 | 2 | 21 | 31 | ||||
| BrainAGE mean (SD) | +3.44 (4.44) | +2.75 (4.94) | -5.29 (2.93) | -2.85 (0.59) | +7.52 (7.64) | +12.18 (7.12) | +5.33 (5.18) | +8.63 (6.69) |