Table 4. Correlation coefficients between BrainAGE scores and cognitive functioning (ADAS scores) as well as disease severity (MMSE & CDR-SB scores) for each diagnostic group and the whole test sample, separately for APOE ε4 carriers and non-carriers.
| NO | sMCI | pMCI | AD | Whole sample | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ε4 carriers | ε4 non-carriers | ε4 carriers | ε4 non-carriers | ε4 carriers | ε4 non-carriers | ε4 carriers | ε4 non-carriers | ε4 carriers | ε4 non-carriers | |
| No. of subjects | 26 | 81 | 14 | 22 | 78 | 34 | 101 | 49 | 219 | 186 |
| Correlation with BrainAGE score at baseline | ||||||||||
| MMSE score | 0.04 | -0.21 | 0.45 | -0.08 | -0.08 | -0.29 | -0.28** | -0.62*** | -0.34*** | -0.52*** |
| CDR-SB score | -0.04 | -0.15 | -0.12 | 0.02 | 0.27* | 0.13 | 0.10 | 0.60*** | 0.29*** | 0.50*** |
| ADAS score | -0.06 | 0.04 | -0.45 | -0.07 | 0.27* | 0.32 | 0.19 | 0.52*** | 0.33*** | 0.50*** |
| Correlation with BrainAGE score at last scan | ||||||||||
| MMSE score | 0.00 | -0.17 | 0.30 | -0.12 | -0.21 | -0.33 | -0.38*** | -0.66*** | -0.44*** | -0.59*** |
| CDR-SB score | -0.07 | 0.00 | -0.07 | 0.09 | 0.38** | 0.23 | 0.21* | 0.59*** | 0.40*** | 0.57*** |
| ADAS score | -0.06 | 0.04 | -0.34 | 0.09 | 0.38** | 0.38* | 0.25* | 0.56*** | 0.43*** | 0.58*** |
***p<0.001
**p<0.01
*p<0.05.