Inflammatory stimuli promoted pancreatic cancer cell growth and invasion in vivo. (A) Chronic inflammatory infiltration of leukocytes, fibroblast proliferation and fibrosis, large regions of acinar loss, and infiltration of CD68+ cells in the pancreas of DBTC-treated mice. (B) The effect of DBTC on pancreatic cancer in representative in vivo bioluminescent images and photographs of cancer xenografts. (C) Bioluminescence of pancreatic orthotopic xenografts. **P < 0.01 as compared to control. (D) Tumor weight of pancreatic orthotopic xenografts. **P < 0.01 as compared to control. (E) Pathological examination of metastatic cancerous nodes and celiac lymph nodes. Green arrow: metastatic cancerous node. (F) Pathological and immunohistochemical examination of pancreatic orthotopic xenografts. Immunohistochemistry was performed using antibodies targeting CD68, CD163, Ki67, CD34, p-IKK (phosphorylated IKK), and PP2Ac.